商品名称：ChIPAb+ REST - ChIP Validated Antibody and Primer Set
一般描述
FUNCTION:Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
SUBUNIT STRUCTURE: Interacts with SIN3A, SIN3B and RCOR1.
SUBCELLULAR LOCATION: NucleusProbable.
TISSUE SPECIFICITY: Ubiquitous. Expressed at higher levels in the tissues of the lymphocytic compartment, including spleen, thymus, peripheral blood lymphocytes and ovary.
SEQUENCE SIMILARITY:Contains 9 C2H2-type zinc fingers.
SEQUENCE CAUTION: The sequence AAA98503.1 differs from that shown. Reason: Frameshift at positions 189, 212 and 1087.
The sequence AAH38985.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence.
The REST purified antibody is made against a GST fusion protein corresponding to amino acids 801-1097 of human REST.
特异性
Recognizes REST, Mr 120-200 kDa.
应用
Epitope: a.a. 801-1097
包装
25 assays per set. Recommended use: ~2 μg antibody per chromatin immunoprecipitation (dependent upon biological context).
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